State police say the collision happened Monday afternoon in the town of Jamaica.
A preliminary investigation shows that a car was traveling southbound on Route 30 when the female driver lost control and the vehicle skidded across the road. It crashed into a northbound SUV driven by 48-year-old Gavin Scotti, of Greenwich, Conn.
Authorities say the car caught on fire shortly after the crash, and the driver was pronounced dead at the scene. Her name is being withheld until family can be notified.
Scotti and his 14-year-old passenger were taken to a hospital to be treated for minor injuries.
Police are investigating the crash.