Vermont State Police said the truck was stopped on state Route 22A in West Haven on Friday night when the bus crested a hill, lost control and careened into the guard rails and the trailer.
The bus driver, Darnell Hannah, 59, of Millstone, N.J., was trapped in the wreckage and died from his injuries, police said. Two of the remaining 31 people on board had moderate injuries and the rest had minor injuries, according to police.
Eight patients were transported to Porter Hospital in Middlebury and 24, including the truck driver, were taken to Rutland Regional Medical Center.
Shari Owens, a spokeswoman for Rutland, said one person was admitted in good condition and the rest were treated and released by 2:30 a.m. Porter Hospital declined to comment on the conditions of its crash victims, citing privacy rules.
Police did not release the name of the tour bus company. Neither the point of origin nor destination of the bus was immediately known.
The road as ice-covered at the time of the crash and police called the conditions a contributing factor. Anyone who witnessed the crash is asked to call state police in Rutland.
West Haven is about 60 miles south of Burlington.