CHARLOTTE, N.C. (AP) -- Cam Newton threw three touchdown passes and ran for another, and Carolina sacked Eli Manning seven times as the Panthers handed Tom Coughlin his worst defeat as coach of the New York Giants, 38-0 Sunday.
It was the largest margin of victory in Panthers history.
The Panthers (1-2) allowed Newton to run out of the read option, which helped open up an offense that had been mostly stagnant this season. Newton had 223 yards passing and threw two touchdown passes to Brandon LaFell and one to Ted Ginn Jr. He ran for 45 yards and his first TD of the season.
BENGALS 34, PACKERS 30
CINCINNATI -- Terence Newman returned a fumble 58 yards for a touchdown with 3:47 left, rallying Cincinnati past Green Bay in a game of wild momentum swings set up by nonstop turnovers.
Each team gave it away four times. Each team returned a fumble for a touchdown -- M.D. Jennings ran one back for Green Bay (1-2). The Bengals blew a 14-point lead, and the Packers let a 16-point lead get away in the second half.
The Bengals (2-1) finished it off when Michael Johnson batted down Aaron Rodgers' fourth-down pass at the Cincinnati 20-yard line with 1:21 left, ending a subpar showing for the quarterback.
Cincinnati's Andy Dalton was 20 of 28 for 235 yards with two touchdowns, an interception and a fumble that Jennings returned 24 yards for a touchdown in the second quarter, sparking Green Bay's comeback.
SAINTS 31, CARDINALS 7
NEW ORLEANS -- Drew Brees passed for three scores and scrambled for New Orleans' first touchdown rushing of the season in a victory over Arizona.
The Saints quarterback was 29 of 46 for 342 yards, with two TD strikes to tight end Jimmy Graham and the other to Robert Meachem.
Brees was intercepted once by New Orleans native and former LSU star Tyrann Mathieu. That play ended a scoring threat, but only delayed the inevitable on a day when Arizona's short-handed defense was little match for the prolific passing attack of the Saints (3-0).
Arizona (1-2) had no answer for the 6-foot-7 Graham, who caught nine passes for 134 yards.
COWBOYS 31, RAMS 7
ARLINGTON, Texas -- DeMarco Murray ran for 175 yards and a touchdown two years after torching St. Louis with a franchise record as a rookie, and Tony Romo threw for three scores in Dallas' rout.
Murray had his first 100-yard game in more than a year.
The Cowboys (2-1) sacked Sam Bradford four times in the first half and had six overall after St. Louis (1-2) hadn't allowed a sack in four games, dating to last season. It was the Rams' longest streak since John Hadl was under center for a division champion in 1973.
Bradford went 29 for 48 and wasn't intercepted.
RAVENS 30, TEXANS 9
BALTIMORE -- Daryl Smith had a 37-yard interception return for a TD, Tandon Doss took a punt 82 yards for another score, and Baltimore smothered Houston's high-powered offense.
The Ravens (2-1) won despite playing without Ray Rice for the first time since 2008. The three-time Pro Bowl running back was replaced by Bernard Pierce, who ran for 65 yards and a touchdown.
Houston (2-1) led 6-3 before Smith picked off Matt Schaub's pass and took it into the end zone with 2:39 left in the first half. Less than two minutes later, Doss had his first punt return for a touchdown.
The Ravens haven't allowed a touchdown in eight quarters since their season-opening 49-27 defeat in Denver.
LIONS 27, REDSKINS 20
LANDOVER, Md. -- Matthew Stafford completed 25 of 42 passes for 385 yards with two touchdowns and one interception, and Calvin Johnson and Nate Burleson both had 100 yards receiving for Detroit, which beat Washington on the road for the first time since 1939.
The Lions (2-1) ended a 21-game streak against the Redskins, the second-longest in NFL history. Detroit's last win away from home in the series came in 1935 against the Boston Redskins, two years before the move to Washington.
Robert Griffin III and the defending NFC East champion Redskins fell to 0-3.
TITANS 20, CHARGERS 17
NASHVILLE, Tenn. -- Jake Locker helped Tennessee end a skid against the San Diego that spanned two states and two decades.
Locker threw a 34-yard touchdown pass to rookie Justin Hunter with 15 seconds left and the Titans rallied to beat the Chargers.
It was their first win over the Chargers for the franchise since 1992 when the team was in Houston and Titans coach Mike Munchak still was playing for the then-Oilers.
The Titans (2-1) had lost nine straight to San Diego.
BROWNS 31, VIKINGS 27
MINNEAPOLIS -- Jordan Cameron caught three touchdown passes, including the go-ahead grab in the back of the end zone with 51 seconds left, and Cleveland kept Minnesota winless.
Third-stringer Brian Hoyer threw for three scores for the Browns (1-2), the latest team to torch Minnesota's depleted secondary. He overcame three interceptions to throw for 321 yards, going 30 for 54. Josh Gordon had 10 catches for 146 yards and a touchdown in his season debut, and Cameron had six receptions for 66 yards.
Christian Ponder ran for two touchdowns for the Vikings (0-3), but he threw an interception, lost a fumble and took his sixth sack on the final play of the game.